Stanford researchers get precise picture of cell target for drugs

It's too bad they didn't include the picture in the press release...

STANFORD, Calif. — More than half of all drugs given to patients work by targeting a particular type of “docking station,” or receptor, found on body cells, to steer the cell’s machinery toward healing an illness. Researchers from Stanford University School of Medicine and the Scripps Research Institute have determined what one of those receptors looks like at the molecular level, giving them the keys to greater control of the process.

A scientific feat, identifying the structure of these docking stations—called G protein-coupled receptors—can direct the future design of drugs that will precisely bind to specific receptors. Precise binding by a drug can stimulate or block that particular receptor’s normal activity, leading to more powerful treatment while minimizing bothersome side effects.

“The majority of hormones and neurotransmitters work through one of these receptors,” said Brian Kobilka, MD, the senior author of three new publications devoted to the structure of a particular G protein-coupled receptor called beta 2-adrenergic receptor. “All these receptors are structurally related, which means that knowing more about a specific one will advance the whole field.”

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